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Largest UK Real-world Evidence study in advanced NSCLC

To the best of the authors’ knowledge, this is the first large-scale, real-world UK study of its kind in this patient population The study cohort accounts for approximately 10% of the total adult first-line treated advanced non-small cell lung cancer population in the UK Electronic prescribing records (EPRs) were the primary data source used in […]

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RWE76 - RCTs finally look beyond RECIST

RCTs finally look beyond RECIST: Treatment beyond first RECIST-defined progression

Post-hoc analysis on an atezolizumab RCT study used treatment beyond first RECIST This endpoint means that RCTs are moving towards being more aligned with real-world evidence studies, which often use TTD Click here and here to read the source articles About SVMPharma SVMPharma is an innovative strategic consultancy, specialising in Real World Evidence (RWE) for the pharmaceutical […]

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RWE75 - RWE supports efficacy of and shows lower toxicity in Kymriah CAR-T Therapy

Real-world evidence supports efficacy of and shows lower toxicity in Kymriah CAR-T Therapy

Two studies looking at patients with diffuse large B cell lymphoma (DLBCL) and acute lymphoblastic leukaemia (ALL) were presented at ASH, looking at Novartis’ CAR-T therapy, Kymriah (tisagenlecleucel). Both studies supported the pre-regulatory approval clinical trials data, with Kymriah achieving high response rates, and in fact saw fewer serious side effects, such as neurotoxicity. This […]

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RWE74 - Real-world data shows drugs’ benefits at ASH 2019

Real-world data shows drugs’ benefits at ASH 2019

Eliquis, Adynovate and Feiba were presented in last month’s ASH 2019 meeting as the subject of studies which showed their benefits through the use of real-world data. Results focused on cost-effectiveness, safety, outcomes and benefits. “Real-world evidence plays a crucial role in understanding patterns of care that happen in day-to-day medical practice outside of rigorous […]

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