001 LN Feb 2020

Real-world data provides the opportunity to enhance regulatory decisions for new drugs

Real-world data and evidence provide valuable performance data on a post-approval drug to create a comprehensive clinical snapshot This can later support regulatory and reimbursement decisions and clinical guidelines More and more stakeholders in the pharmaceutical pipeline are recognising the value of real-world data Click here to learn more About SVMPharma SVMPharma is an innovative strategic consultancy, […]

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001 VN Feb 2020

Cancer Electronic Prescribing Records – Real-world Data

  Electronic prescribing records, or EPRs, are a rich untapped source of real-world evidence SVMPharma’s unique EPR real-world studies are one step ahead of the Systemic Anti-Cancer Therapy (SACT) data set Click here to learn more About SVMPharma SVMPharma is an innovative strategic consultancy, specialising in Real World Evidence (RWE) for the pharmaceutical industry. SVMPharma […]

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006 Mailing  infograhic-SVM 2.0

Largest UK Real-world Evidence study in advanced NSCLC

To the best of the authors’ knowledge, this is the first large-scale, real-world UK study of its kind in this patient population The study cohort accounts for approximately 10% of the total adult first-line treated advanced non-small cell lung cancer population in the UK Electronic prescribing records (EPRs) were the primary data source used in […]

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RWE76 - RCTs finally look beyond RECIST

RCTs finally look beyond RECIST: Treatment beyond first RECIST-defined progression

Post-hoc analysis on an atezolizumab RCT study used treatment beyond first RECIST This endpoint means that RCTs are moving towards being more aligned with real-world evidence studies, which often use TTD Click here and here to read the source articles About SVMPharma SVMPharma is an innovative strategic consultancy, specialising in Real World Evidence (RWE) for the pharmaceutical […]

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RWE75 - RWE supports efficacy of and shows lower toxicity in Kymriah CAR-T Therapy

Real-world evidence supports efficacy of and shows lower toxicity in Kymriah CAR-T Therapy

Two studies looking at patients with diffuse large B cell lymphoma (DLBCL) and acute lymphoblastic leukaemia (ALL) were presented at ASH, looking at Novartis’ CAR-T therapy, Kymriah (tisagenlecleucel). Both studies supported the pre-regulatory approval clinical trials data, with Kymriah achieving high response rates, and in fact saw fewer serious side effects, such as neurotoxicity. This […]

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RWE74 - Real-world data shows drugs’ benefits at ASH 2019

Real-world data shows drugs’ benefits at ASH 2019

Eliquis, Adynovate and Feiba were presented in last month’s ASH 2019 meeting as the subject of studies which showed their benefits through the use of real-world data. Results focused on cost-effectiveness, safety, outcomes and benefits. “Real-world evidence plays a crucial role in understanding patterns of care that happen in day-to-day medical practice outside of rigorous […]

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RWE73 - Largest UK RWE Study of Sequenced 2nd generation TKIs in CML

Largest UK RWE Study of Sequenced 2nd Generation TKIs in CML

This weekend at the 61st American Society of Haematology Annual Meeting and Exposition in Orlando, Florida, SVMPharma and Incyte’s study on chronic myeloid leukaemia (CML) was presented as a poster. This study was the largest UK real world evidence study in CML patients who had been sequenced to a 3rd line tyrosine kinase inhibitor (TKI) […]

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RWE72 - Real World Evidence Driving Decision Making in Oncology

Real World Evidence: Driving Decision Making in Oncology

Oncology prescribing practices rely heavily on the data from clinical trials. However, due to lesser patient numbers found in clinical trials, knowledge gaps start presenting themselves in the form of understanding disease progression, overall survival, efficacy etc. Information like this can be collected in real world evidence studies so that more personalised treatment pathways can […]

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RWE71 - Real-world Evidence Allows for Customised and Precise Treatment

Real-world Evidence Allows for Customised and Precise Treatment

New data and technology can drive tailored treatments through physician education Real-world evidence shows comparative effectiveness, which is valuable when determining the ideal patient management scheme “A randomized clinical trial is trying to show efficacy. It asks, how well does this work under optimal circumstances? In contrast, a real-world evidence study is trying to show […]

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019 RWE Ideas Nov 2019

RCT Vs Real World Evidence

RCTs primarily generate efficacy; complement them with real-world evidence studies to generate effectiveness. Find out if a drug works in a real-life setting, with real patients. Determine when, how often and why a drug is used in a prescribing line. Retrospectively review patients for long periods of time. About SVMPharma SVMPharma is an innovative strategic […]

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